tag:blogger.com,1999:blog-8860166.post114643915812209882..comments2024-02-11T00:54:20.373-08:00Comments on A Trail Runner's Blog: URB597 - Runners High in a Pill?Scott Dunlaphttp://www.blogger.com/profile/16096284778835123584noreply@blogger.comBlogger9125tag:blogger.com,1999:blog-8860166.post-31444003210209723122011-09-16T06:28:17.432-07:002011-09-16T06:28:17.432-07:00Hi Scott. i just wrote this long comment and it go...Hi Scott. i just wrote this long comment and it got erased by mistake. ooff [as we say in israel to express something disappointing].<br /><br />i was really impressed and enthusiastic about the idea of getting and starting a running regime, hopefully being able to be in a good enough shape to feel the "runners high" you mentioned. i got here after reading a lot about the urb597 and as i hope development of it will be soon as i suffer from a lot of depression problems which many antidepressants didn't resolve. <br />so i thought if i could get the energy and the motivation to start running regularly and get in good shape [right now only able to run for a half hour] it might bring something of this positive feelings, at least another factor that could help..<br /><br />so i was wondering if you could share with me information of how to be able to sustain such extreme exercise on a regular schedule without tearing your body too much and cause stopping this..<br />any info like how to prevent injuries and strains with such long running [of course hoping to get there slowly], i know there could be knee problems and things like that and wondered how do you [or other known information you could link me to] prevent and keep that from happening..<br /><br />any info and tips would be greatly appreciated. <br />with my most respect to your wonderful blog and sharing this great thing with others, thanks,<br /> <br />Noam.<br /><br />habubs@gmail.com<br /><br />by the way, i hope you get to read comments from way back like this one.Noamnoreply@blogger.comtag:blogger.com,1999:blog-8860166.post-37128989969876970252008-08-17T23:08:00.000-07:002008-08-17T23:08:00.000-07:00actually, endorphins are most likely responsible f...actually, endorphins are most likely responsible for runner's high, not so much anandamide according to a study done at Georgia Tech in 04. Also, a German study has recently shown that there is higher opioid receptor activity after running, which would make sense that there would be a high afterward due to the intoxicating effects of opiates.Anonymousnoreply@blogger.comtag:blogger.com,1999:blog-8860166.post-18615859609935536282007-11-26T06:42:00.000-08:002007-11-26T06:42:00.000-08:00Also from Reddit -To be correct, URB597 is a fatty...Also from Reddit -<BR/><BR/>To be correct, URB597 is a fatty acid amide hydrolase inhibitor, so it blocks the catabolism of anandamide.Anonymousnoreply@blogger.comtag:blogger.com,1999:blog-8860166.post-51212931078120247742007-11-26T06:40:00.000-08:002007-11-26T06:40:00.000-08:00Cut and pasted from Reddit -Our ED50 for producing...Cut and pasted from Reddit -<BR/><BR/>Our ED50 for producing stimulus effects in rats and mice WITH co-administration of a low dose of anandamide was about 3 mg/kg. So if you want to try this you're going to need somewhere over 200 mg from cayman chemical and this will run you in the hundreds of dollars... (not to mention it will be a one time thing) I think I'll stick to my bag of herb for now ;)Anonymousnoreply@blogger.comtag:blogger.com,1999:blog-8860166.post-44219754440464425482007-11-25T04:45:00.000-08:002007-11-25T04:45:00.000-08:00endocannabinoids are neurochemicals, not neurons.endocannabinoids are neurochemicals, not neurons.Anonymousnoreply@blogger.comtag:blogger.com,1999:blog-8860166.post-33563932081706810592007-09-17T12:31:00.000-07:002007-09-17T12:31:00.000-07:00I am a 50 something woman who has always been very...I am a 50 something woman who has always been very physically active but now have nerve issues that keep me from doing the intense work out it takes to get the 'high' I need to keep from being depressed.<BR/>Partook a bit 2 years ago and a part of my brain got unlocked that I hadn't seen in over 20 years. I live where it is illegal and I am a good citizen. So, I am perplexed and do not even know if it is safe to tell my physician about this whole thing. I am one who began getting high on cannabis when i was only 14. I destroyed my brain's natural ability to produce this chemical. so, any help...Anonymousnoreply@blogger.comtag:blogger.com,1999:blog-8860166.post-24601145986253000422007-07-18T19:30:00.000-07:002007-07-18T19:30:00.000-07:00I've read theories that endogenous DMT may play a...I've read theories that endogenous DMT may play a role in 'runners high.' I wonder if anyone knows for sure. <A HREF="http://www.loveleafgarden.com/raw_cacao" REL="nofollow">Cacao</A> contains anandamide. A few tablespoons of raw cacao nibs has noticable euphoric effects, but I hear the levels of anandamide are pretty low.Anonymousnoreply@blogger.comtag:blogger.com,1999:blog-8860166.post-1146693973606716392006-05-03T15:06:00.000-07:002006-05-03T15:06:00.000-07:00Cool post. I don't often feel a physical "high" b...Cool post. I don't often feel a physical "high" but there's no doubt I'm happier and healthier then I've ever been with my endurance training. And often I will tell my road running buds that I need to "recharge the batteries" by getting out on a trail.-https://www.blogger.com/profile/10852821881248111596noreply@blogger.comtag:blogger.com,1999:blog-8860166.post-1146655039439527492006-05-03T04:17:00.000-07:002006-05-03T04:17:00.000-07:00URB397 might help getting a 'runner's high' withou...URB397 might help getting a 'runner's high' without running; but there's more to running(sights, getaway, etc) than just the high..So if you want the whole package, GO RUN! :-)Arbithttps://www.blogger.com/profile/04310587001706149255noreply@blogger.com